NEW TOOL! Screening 3-11 Helix: This module allows user to screen large databases in order to find sequences that have the general physico-chemical features of a target 3-11 helix sequence.

News :2011-07-05 HeliQuest version 2 with new screening module for 3-11 helix and module Analysis for several helix type (α-helix, 3-10 helix, 3-11 helix or π helix) 2011-06-24 Update of SwissProt Databases 2010-12-01 New server, more powerful and fast, Update of the SwissProt Databases 2010-02-02 Update of the SwissProt Databases2009-04-04 Update of the SwissProt Databases 2008-09-10 Update of the SwissProt Databases 2008-07-01 HeliQuest v1.2 online

I have seen posts from many people mentioning using tapered endmill and I can’t seem to find much information on these. I looked in the Wiki but did not see anything, it does not appear in the endmill section but maybe I missed something.

I use tapered end mills for the finishing pass and path engraving pass on my terrain relief model carvings. They get me the detail of a very small ball-nose end mill but with much longer reach, allowing me to make deeper carves without crashing the collett into the walls.

As for procuring tapered mills, I use basically the same ones as Stuart gets on eBay, but I get mine at Amazon in various sizes. (They’re probably from the same source in China, so it’s just whatever source is convenient, really.) Basic two-flute 1/4" shank, 31.75mm flute length, with whatever taper angle geometry requires for a given tip radius.

Please cite the following reference: Gautier R., Douguet D., Antonny B. and Drin G. HELIQUEST: a web server to screen sequences with specific α-helical properties. Bioinformatics. 2008 Sep 15;24(18):2101-2.

Could someone provide where I can find information as to when to use them, how are they defined in Carbide Motion, what to look for when getting one e.g.: number of flutes or size of taper, etc. material where they can be used successfully.

Basically they are the same as a ball end mill, but let you have a much finer ball on the end, giving you a lot more detail, but because of the taper to a 1/4" shank they are a lot stronger so you can take deeper/wider cuts with them

Screening α-Helix:This module allows user to screen large databases in order to find sequences that have the general physico-chemical features of a target α-helix sequence.

HeliQuest calculates from an helix sequence (α-helix, 3-10 helix, 3-11 helix or π helix) its physicochemical properties and amino acid composition and uses the results to screen any databank in order to identify protein segments possessing similar features. The server is divided into 2 interconnected modules: the sequence analysis module and the screening module for α-helix sequence and for 3-11-helix sequence. In addition, the mutation module, (available from the sequence analysis module), allows user to mutate helices manually or automatically by genetic algorithm to create analogues with specific properties.

NEW! MODIFICATION:This module is dedicated to characterizing helices known by the user. It determines properties as hydrophobicity, hydrophobic moment, z and amino acid composition for several helix types (α-helix, 3-10 helix, 3-11 helix or π helix). Note 1: The link to the screening module is available only if user analyzes sequences with an 18 a.a. window (α-helix only). Note 2: A sequence can be modified by the manual or GA-based mutation modules once analysed (α-helix only).