Featuring high speed steel construction, this Titan USA offering of Jobber Length Drills is engineered with a 118° point and Black Oxide finish, which increases wear resistance and improves lubricity.

BMY-28090 is a novel actinomycete fermentation derived antitumor agent. The cytotoxic effect of BMY-28090 was evaluated in two murine and eight human tumor cell lines in vitro. Following 72-hour exposures, BMY-28090 was cytotoxic for all of these cell lines with IC50 values of less than 0.02 to 3.25 micrograms/ml. BMY-28090 was evaluated for in vivo antitumor activity in a variety of experimental murine tumor and human tumor xenograft models. Initial testing against the murine tumor models was performed using BMY-28090 as the water insoluble free base whereas subsequent antitumor tests were performed using water soluble lactate or succinate salts. BMY-28090 administered ip demonstrated good, reproducible antitumor activity against ip implanted P388 leukemia, L1210 leukemia, B16 melanoma and M5076 sarcoma. The water soluble preparations of BMY-28090 were active iv against sc implanted B16 melanoma and M5076 sarcoma as well as subrenal capsule (src) M5076 sarcoma; activity against src implanted B16 was marginal. BMY-28090 lactate was also evaluated for activity against src implanted MX-1 human mammary tumor xenografts in nude mice and the HCT116 human colon tumor xenografts in immune-suppressed BDF1 mice. At maximum tolerated doses administered ip, BMY-28090 was active against the MX-1 xenograft in two of three tests, causing greater than 90% inhibition of tumor growth. BMY-28090 administered iv at maximally tolerated doses had marginal activity against the HCT116 xenografts, producing 61% and 68% inhibition of tumor growth in two tests. The results of these studies demonstrated that BMY-28090 has a broad spectrum of in vitro cytotoxicity against both murine and human tumor cell lines.(ABSTRACT TRUNCATED AT 250 WORDS)

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These Titan USA Drills are available with either a Bright finish, which improves performance in plastics and other non-ferrou. . .

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This fully stocked, high speed steel offering of Stub Length Titan USA Drills features a 135° split point and Black Oxide fin. . .

Titan USA earned its stellar reputation by providing machinists like yourself with premium quality, American-made cutting tools. When you're in need of everything from end mills and drills to taps and reamers, Trust in Titan USA to deliver the best quality tooling at incredible value.

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The Black & Gold Oxide finish, featured on the drills within this selection of Titan USA Jobber Length High Speed Steel Drill. . .

Titan USA earned its stellar reputation by providing machinists like yourself with premium quality, American-made cutting tools. When you're in need of everything from end mills and drills to taps and reamers, Trust in Titan USA to deliver the best quality tooling at incredible value.

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