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The RCV accession number, with most recent version number, for the variant-condition record, with a link to the RCV web page.

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

If you have artwork in an image format, Carbide Create can trace that image and convert it to vectors that are ready to cut.

The global minor allele frequency calculated by the 1000 Genomes Project. The minor allele at this location is indicated in parentheses and may be different from the allele represented by this VCV record.

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Organisation/RTO details for 45350 - Monash Education Group Australia Pty Ltd.

Vector offsets allow you to select a vector or shape and create a copy that's offset by some distance from the original one. You can offset to the inside or outside.

The submitting organization for this submitted (SCV) record. This column also includes the SCV accession and version number, the date this SCV first appeared in ClinVar, and the date that this SCV was last updated in ClinVar.

Stars represent the aggregate review status, or the level of review supporting the aggregate germline classification for this VCV record. This value is calculated by NCBI based on data from submitters. Read our rules for calculating the review status. The number of submissions which contribute to this review status is shown in parentheses.

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The number of variants in ClinVar for this gene, including smaller variants within the gene and larger CNVs that overlap or fully contain the gene.

The aggregate germline classification for this variant-condition (RCV) record in ClinVar. The number of submissions that contribute to this aggregate classification is shown in parentheses.

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Stars represent the review status, or the level of review supporting the submitted (SCV) record. This value is calculated by NCBI based on data from the submitter. Read our rules for calculating the review status. This column also includes a link to the submitter’s assertion criteria if provided, and the collection method.

The condition for the classification, provided by the submitter for this submitted (SCV) record. This column also includes the affected status and allele origin of individuals observed with this variant.

Carbide Create is a great way to go for 2D and 2.5D CAD/CAM. If you need 3D toolpaths then we've got two options for you.

The .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Booleans are an incredibly powerful way to combine simple shapes into more complex ones, so you don't have to create them from scratch.

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Carbide Create is included with both Nomad Desktop CNC and Shapeoko CNC routers so you don't have to spend hundreds of dollars on software to go with your new machine.

This date represents the last time this VCV record was updated. The update may be due to an update to one of the included submitted records (SCVs), or due to an update that ClinVar made to the variant such as adding HGVS expressions or a rs number. So this date may be different from the date of the “most recent submission” reported at the top of this page.

Carbide Create has all the common toolpath options to cut your project, from simple 2D cutouts to detailed multi-tool designs.

Nov 4, 2023 — Indexing Heads and Rotary Tables: These devices are used when workpieces require multiple machining operations at different angles. They provide ...

This column includes more information supporting the classification, including citations, the comment on classification, and detailed evidence provided as observations of the variant by the submitter.

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Whether you're looking to just make sure the parts are in proportion or you need to carefully trace an image, having a reference image will speed up your design cycle.

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All of the tools in the Carbide 3D tooling store are included in the tool library, so you can quickly select the right tool for the job.

This tracing function was designed from the gound up to work with CNC routers, so it creates simple, clean vectors that are easy to machine, not connected shapes that require a lot of editing.

Don't have Wi-Fi in you shop? No Problem. Carbide Create runs on your computer locally. It does not depend on the cloud or any online connection to function.

Cytogenetic: 6p21.32 6: 32840819 (GRCh38) [ NCBI    UCSC ] 6: 32808596 (GRCh37) [ NCBI    UCSC ]

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Pocket toolpaths clear the area inside of a vector, while contours cut along the inside or outside of a vector. These operations are the basis for most machining jobs.

Carbide Create runs on modern Mac or Windows computers. Files produced in Carbide Create can be freely moved back and forth between either operating system.

Carbide Create includes speeds and feeds for many common cutters and materials, so you don't have to figure them out on your own.

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If your design is already done and you just need to create toolpaths, that's no problem- load your file and start creating toolpaths.

If you need to start your design from another program or file, you can load SVG and DXF files directly into Carbide Create.

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Carbide Create includes all the design tools to start your design from a blank page. If you're familiar with programs like Adobe Illustrator or Corel Draw, you'll feel right at home in Carbide Create.

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If you need to make parts that fit perfectly, the alignment tools in Carbide Create will help you put all the sections of the design in the correct locations.

The aggregate review status for this variant-condition (RCV) record in ClinVar. This value is calculated by NCBI based on data from submitters. Read our rules for calculating the review status.

The aggregate germline classification for this variant, typically for a monogenic or Mendelian disorder as in the ACMG/AMP guidelines, or for response to a drug. This value is calculated by NCBI based on data from submitters. Read our rules for calculating the aggregate classification.